Controlled Hypotension in Neurosurgery with Hexamethonium and Procaine Amide

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The action of procaine and procaine amide on the heart.

The depressant action of procaine on the heart muscle has been the subject of several clinical and experimental studies (Wiggers and Wegria, 1940; Burstein, 1946; Uhley and Wilburne, 1948; Schaffer et al., 1950). Procaine was found useful in the treatment of cardiac arrhythmias occurring in anesthetized patients during cardiac surgery. However, its usefulness in the management of clinical arrhy...

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Prophylactic procaine amide in myocardial infarction.

Of patients with myocardial infarction who survive long enough to be admitted to hospital, ten per cent die suddenly and often unexpectedly (Wood, 1956). Whereas deaths from overwhelming shock, congestive cardiac failure, or cardiac rupture are usually inevitable, due to the massive destruction of cardiac muscle, the sudden deaths may be more tragic in that they may occur in patients with appar...

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A Case of Unilateral Involuntary Movements Treated with Procaine Amide

no history of previous mental or nervous illness. He had worked regularly as a platelayer on railway for some 47 years till his retirement at 65 years of age; since then till the onset, :ed illness he had worked regularly as a jobbing gardener. He was happily married and den any significant family or personal history. te He had been well until six weeks prior to admission. Then he had suffered ...

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The Antiarrhythmic Properties of Lidocaine and Procaine Amide

THE operative management of patients with congenital or acquired heart disease is often complicated by the occurrence of ventricular arrhythmias. Bigeminal rhythm or premature ventricular contractions are frequently noted with the induction of anesthesia, with tracheal intubation, during dissection and manipulation of the heart and great vessels, and with nasotracheal aspiration in the postoper...

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Vascular Effects of Procaine Amide in the Dog

The mechanism of the vasodilator effect of procaine amide in dogs was investigated in isolated gracilis muscle and hindpaw perfused at constant flows with arterial blood. Inhibition of sympathetic ganglionic transmission contributed predominantly to the vasodilatation in muscle that accompanied intravenous administration of procaine amide (20 mg/kg). In contrast, comparable amounts of procaine ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1953

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.4817.961